Novocaine

Steve Martin

Frank Sangster

Helena Bonham Carter

Susan

Laura Dern

Jean Noble

Lynne Thigpen

Pat

Chelcie Ross

Mike

Polly Noonan

Sally

JoBe Cerny

Pharmacist Wayne Ponze

Elias Koteas

Harlan Sangster

Yasen Peyankov

'Sunshine Lounge' Bartender

Scott Caan

Duane

Teri Cotruzzola

Attractive Complaining Patient

Lucina Paquet

Mrs. Langston

Preston Maybank

Gelding

Sally Kao

Chinese Wife

Quincy Wong

Chinese Husband

George Lugg

Liquor Store Owner

Tyler Rostenkowski

Billy

Tom Milanovich

'Blue Sands' Bartender

Karol Kent

Detective Lily Pons

Keith David

Detective Lunt