Paulie

Gena Rowlands

Ivy

Tony Shalhoub

Misha Vilyenkov

Cheech Marin

Ignacio

Bruce Davison

Dr. Reingold

Trini Alvarado

Adult Marie Alweather

Jay Mohr

Benny / Paulie (voice)

Buddy Hackett

Artie

Hallie Eisenberg

Marie Alweather

Matt Craven

Warren Alweather

Bill Cobbs

Virgil the Janitor

Tia Texada

Ruby / Lupe (voice)

Laura Harrington

Lila Alweather

Peter Basch

Graduate Student #1

Emily Mura-Smith

Graduate Student #2

Hal Robinson

Grandpa

Tamara Zook

Speech Therapist

Nicole Chamberlain

Shirley

Charles Parks

Gerald

Seth Mumy

Jeremy

Dig Wayne

Research Assistant #1